Inorganic elements play important role in medical and biological fields
Inorganic elements play important role in medical and biological fields, and it is evident that most of the organic compounds used in medicine does not possess a purely organic mode of action, some are activated or bio transformed in to metabolites in the presence of metal ions. Many organic compounds on coordination with metal ions possess enhanced pharmacological and toxicological properties. Schiff bases are important class of compounds containing azomethine or imine group which are formed under acids or base catalysis or with heat. The common Schiff base are crystalline solids, which are feebly basic but at least some form insoluble salts with strong acids. Schiff base are used as ligands for preparation of metal complexes having different structures or as intermediates for the synthesis of amino acids. Schiff bases also behaves as a Flexi-dentate ligand and commonly co-ordinates through the O atom of the de -pronated phenolic group and with the lone pair of electrons present on the N atom of azomethine group.3 In Schiff base nitrogen of the azomethine group and other donor atoms like oxygen play a very important role in co-ordination chemistry. Hence an attempt is made to study the interaction of reduced Schiff base with transition of metals of biological interest and to investigate the coordination chemistry of such interactions. Schiff bases possess broad spectrum of biological activity and incorporation of metals in form of complexes have gained importance in medicinal and pharmaceutical fields due to a broad spectrum of biological activities like antimicrobial 9, 10, anticonvulsant 11, anti-inflammatory 4–7, antioxidant 15, analgesic 5–8, anticancer 13, 14, anthelmintic 16, antitubercular 12, and so forth. In the azomethine group, it is the nitrogen atom which forms a hydrogen bond with the active centers of cell constituents and interferes in normal cell processes 17, 18. Studies enlightened that metal complexes show greater biological activity than free organic compounds 20. Schiff bases are also used as polymer stabilizers 3, intermediates in organic synthesis, catalysts, corrosion inhibitors 19 pigments, and dyes. Augmentation of biological activity was reported by implementation of transition metals into Schiff bases 21. Schiff bases played an important role in development of coordination chemistry and were involved as key point in the development of inorganic biochemistry and optical materials 22. Schiff bases have been utilized as synthons in the preparation of a number of industrial and biologically active compounds like formazans, 4-thiazolidinines, benzoxazines, and so forth, via ring closure, cycloaddition, and replacement reactions 23. Schiff base derivatives in various processes promoted the researchers for designing of novel heterocyclic/aryl Schiff bases for development of new environmental-friendly technology 24. Formation of Schiff base generally takes place under acids or base catalysis or with heat. The common Schiff base are crystalline solids, which are feebly basic but at least some form insoluble salts with strong acids. Schiff base are used as intermediates for the synthesis of amino acids or as ligands for Preparation of metal complexes having a series of different structures. A Schiff base behaves as a Flexi-dentate ligand and commonly co-ordinates through the O atom of the de -pronated phenolic group and the N atom of azomethine group.3 In Schiff base azomethane nitrogen and other donor atoms like oxygen play a vital role in co-ordination chemistry. Hence an attempt is made to study the interaction of reduced Schiff base with transition of metals of biological interest and to investigate the coordination chemistry of such interactions.
